Heh, is everyone afraid of this topic? Okay, I'll bite. :P Do you want modern or classic? PC or console? Visual novel, dating sim, anything? I'm assuming English is a must?
For just a general recommendation, Welcome to Pia Carrot!! is a high quality game (see here: http://www.honestgamers.com/reviews/3681.html), and the PC-FX version, often considered the best, has been fan translated: http://projects.mattsmessyroom.com/welcometopiacarrot/
What's awesome is that you can just burn the patched game to a disc and play it on a real PC-FX, but assuming you don't have this obscure system, you can always just emulate.