I was reading about this on the Magic Engine forum:
http://www.zeograd.com/super_hucard_download.php
I haven't tried it but evidently you can hack the 4-in-1 turbo grafx iso to play any hucard game if you burn the rom to a cd-r.
I wonder if this would work for the sega cd if you used the sega classics compilation that had streets of rage, revenge of shinobi, and columns? I'm guessing that these games were, in fact, roms and were not being emulated but played using the genesis hardware.