Currently, this title is still held by Battletoads vs. Double Dragon, but can you think of any other pairs of video game stars that would go about as well together as peanut butter, chocolate, and ketchup?
I think Bomberman vs. Mighty Bomb Jack would make a pretty awful game. Bomberman plants explosives, while Mighty Bomb Jack picks them up and diffuses them. Or how about Pressure Cooker vs. Burgertime? Short Order Sam slaves away making burgers, and Peter Pepper ruins all his hard work by stepping all over them.
Some video game characters just don't belong together. It's up to you to decide just which ones should be kept apart.

JR