There's nothing like that moment when you first pop in Gunstar Heroes and head to the jungle stage. Tons of enemies rush you, and you're running and jumping and firing in every direction, filling the screen with explosions. It's by far my favorite video game adrenaline kick.

Heck, any well made shooter is a great source of nonstop destruction. I love frying everything in sight with a high-powered beam in ESP Ra.De or Dodonpachi.