Do you HAVE to use the Masterball to catch Mesprit?

[tofu]

Took me six tries, but I just used a quickball everytime. Either I got lucky or you're trying too hard.

btw those comic strips are great, where are they from?

[JSoup]

btw those comic strips are great, where are they from?

First two are from Penny Arcade, the third is from VGCats.

[Blitzwing256]

if you can manage to keep him asleep and confused (confuse is the only status ailment that stacks) it'll have temendously, keep him unconscous and keep using random balls, dusk balls might be your best bet if you're fighting him at night, if you can manage to keep him from running for about 30 turns, the timer ball will work great.

like others have said it is random if the balls work sometimes you can get him with a pokeball first try, and sometimes it'll take 200 ultraballs, just be persistant and patient. (or just play through pokemon collesium to get a masterball and use that. might actually take less time if you know what you're doing in collesium)