MAME, Moduler (Model 2 emulator) and final burn + MAS or Real Arcade pro (I use both)
Supergun or consolized AES/Atomiswave/Type X (if consolized Type X boards exist)
A basement full of cabs?
Option 1 for me I have a real arcade pro and 2 Mas sticks I use (some Type X games don't like my sticks though)