Myst was excellent, as was Riven (I haven't played the rest in the series yet).

Lately I was at Goodwill and discovered a (complete and boxed) copy of a game called Timelapse, which was also a Myst-like, but with a slightly different control scheme (you still point in click but you can move around with the WASD, and when you do so an indicator of available directions shows up. I find this valuable for letting me know when I can zoom in on objects or otherwise might have missed a detail). So far, Timelapse is pretty good and with an entertaining concept.

And now I'm in love with this genre. I mean, I understand why Myst-likes were hated, but screw haters.

Anyway, what are some of your favorite Myst-like games?