Klonoa for me.

When I saw that ending, and the music that played throughout, I burst into tears uncontrolably. Never have I ever felt such emotions as in that game. Sure, I remember playing Illusion of Gaia and loving the ending, but it was no where near the emotional level I had when I finished Klonoa.

And even now, while pre-ordering the game for the Wii, I almost cried, remembering the ending that once brought me a new level of emotions.

IMO, if a person cries in a game, then it trully is one helluva game.