Not even the 20/60gig models are immune. I ran into a problem of my own yesterday. I tried playing Crisis Zone on a 60gigger with the new 2.00 firmware, and it wouldn't work properly. The brightness test in the beginning failed every time, and only the last shot from the machine gun did anything. It was possible to pull back and forth on the trigger really fast to get somewhere in the game, but it was so annoying and pointless and would probably cause you to run out of time anyway. I'd imagine the extra mode with the handgun and the shotgun would work better when using those weapons, but I've got to hope I don't accidentally pick up a flamethrower. It's so annoying because not only does Time Crisis 3 work, but the machine gun in Time Crisis 3 works perfectly. So I had to play Crisis Zone on my PS2 which I haven't touched in months. What a load.
So, give us your game of choice, your firmware version (if known), and what model you're playing it on. 40gig owners need not apply.