Yes. Lots, actually. I've probably done it a dozen times, and it really messes up your rhythm when it happens.
So far, my instruments have held up fine, though I've only used the guitar once because I like the Guitar Hero ones more. I do seem to have an issue with the red pad on the drums, but it may just be my playing style. I'll hit the pad and it doesn't register occasionally even though I know I hit it -- I frequently break streaks because of it. I don't have any such issues with the other pads. It seems to work fine in menus, so I guess I might not be hitting it right while I play.