I guess this is a first, noticed it while cruising around Amazon today. It's a US NTSC version, but tagged with "En Espanol" graphics and a Hispanic cover athlete. I assume the commentary (and perhaps the soundtrack?) is in Spanish, along with in-game menus, etc.
http://www.amazon.com/s/ref=nb_ss_gw...spanol&x=0&y=0
For Xbox 360 and PS3.
EDIT: looks like there was an En Espanol version of Madden 08 for PS2 and Xbox 360 last year. Don't remember hearing anything about that, though. Anybody have one?