That happened to me, fellas. I wasn't playing my games anymore; for some reason, I couldn't bring myself to...it felt too much of a hassle, you know? Plugin it in, choosing a cart, etc, etc, etc.
So after a few months like that, I finally find an affordable copy of Super Metroid (they're expensive around here). And it rekindled my interest for gaming again...after beating it (in shameful 8h30m), I felt like playing again! Now I'm taking on SMB on the NES with my daughter again, giving Gunstar Heroes a try on hard mode, dusting off my PSX to resume my Skullmonkeys game. All thanks to Super Metroid!
Has something like that ever happened to you? Has a single gamed ever revived your interest in playing?