Originally Posted by
Rev. Link
When I first played mine, I played it at work under fluorescent lights, and it did give me a bit of a headache. But later that night, after I got home, I played it a bunch more and I felt fine. Some people have been saying that the fluorescents make it mess with your eyes more because of them reflecting off of the top screen. I don't know if that's true, or I just got used to it.
The next day at work I played some more, and felt fine, though I didn't play very long. So don't give up on it entirely. You could just need an initial adjustment period.