Yup, the games that make that certian button or trigger loose or broken We have all experienced this... Feel free to add to this
PSP-
Coded arms- you need to click the damn trigger at least 5 times to kill somebody, easy way to loosen up the R button
Dark stalkers- An all around button masher, though not hard on a specific button
Socom FTB Beta- You press R and x a LOT!!.
GBA-
yoshi's island- made my right trigger un-clickable
Metroid zero mission- also makes the right trigger un clickable if played long enough