Just Cause 2 for the 360 reached unplayability for me when it just decided all characters including mine would have no upper torso. You could switch weapons and fire them, drive vehicles, etc. but no upper body. Also, went to reload past save and there was nothing there in the save file. Then when I got out of the save file, all the NPCs were gone. I still had no upper torso but everywhere I went there were no other people.
I just had to give up on RDR Undead Nightmare downloaded for Xbox One. Deep into the game, all zombies and some NPCs had no heads and some of them had no arms. Then NPCs you were required to help to progress the game disappeared off the map and zombies just kept respawning so you couldn't save the town. It was such a shitshow I ended up just deleting it.