I played RE 4 for the first time back in December (yeah late to the party, I know) and the part that sent chills down my spine the most was the part where you're in the lab and you see on one of the monitors that creature entire the room. The music suddenly changes. You see the creature a few rooms over start to approach you. It turns liquid like and pours over the windows of shattered glass. He makes a disturbing "heheh" sound. You're supposed to kill the creature using a rifle with an infrared scope, hitting it in select spots. The sight of that thing walking closer while in infrared mode...jesus. Even when you took out its legs it would start to lead up at you. Even thinking about now raises hairs on my back.