What are some great console exclusive titles that have never been ported to a console newer than what the game was first released on?
For example the Mega Man games wouldnt apply because they reappeared in the Anniversary Collection.
Off the top of my head Little Samson is the first one I can think of. It was only released on the NES and the only way to play it today is either through piracy or on a NES cart
Others:
Joe and Mac 2 (SNES)
Legend of Legaia (PS1)
Medievil (PS1)
Rocket Robot on Wheels (N64)
Seaman (DC)
Sega Marine Fishing (DC)
Super Mario Sunshine (GC)
Downhill Domination (PS2)