Yup, the games that make that certian button or trigger loose or broken We have all experienced this... Feel free to add to this

PSP-

Coded arms- you need to click the damn trigger at least 5 times to kill somebody, easy way to loosen up the R button

Dark stalkers- An all around button masher, though not hard on a specific button

Socom FTB Beta- You press R and x a LOT!!.

GBA-

yoshi's island- made my right trigger un-clickable

Metroid zero mission- also makes the right trigger un clickable if played long enough