As for video settings, no. At least not the kind that you would look for with something like this. There is an option for "flash" which seems to reduce "light effects" (presumably for people who don't want to risk seizing from bright flash lights, etc.) The rest of it seems to be specifying the actual position of the screen and such. Nothing that seems very useful.

As for "supporting s-video", I was under the impression that that was something that was done on the hardware level rather than the software level. I could be really off-base on this, but I didn't even think it was possible for a game to not support s-video unless the system hardware itself didn't support it.