I would say 2 come to mind for me. First would be the Game.com, I got one of these for my birthday as a kid instead of a gameboy color. It looked so cool and advanced... but i pretty much sucked. Terrible touch screen controls, black & white graphics that were hard to see, and a bad game library. The other would be PC (not sure if this counts). I've never been a PC gamer and just don't really enjoy it for whatever reason.

I'm sure there would be more, but i havent played a lot of the obscure and older systems