Nope. MVS and AES carts boot in the region of the console or arcade board they're plugged into. The AES, MVS, and all regions available are programmed onto every cart, home or arcade. Many games alow region select in their menus. So, basically, a Japanese cart acts like a US cart in a US system, and a US cart acts like a Japanese cart in a Japanese system. European carts are the same way. Region is a non-factor with a couple of exceptions like the Quiz games thar only have Japanese versions.