I would say my favorite 16-Bit system is the Sega Genesis, that system was/is awesome! I just love it so much there are so many great games, And the system itself is cool(with the option for headphones and all)

Anyway, it's a tie between a couple of different games for my favorite 16-bit title of all time...

Sonic 2(Genesis) I love just about everything about this game, the fun secret filled gameplay, the sense of speed, the colorful graphics, the awesome music. This is what a 16-bit title is all about! I just wish the multi-player was better.

Streets of Rage 2(Genesis) I've spent so many hours on this game, it just never gets old to me. I've made all my friends hate this game by making them play through this game hundreds of times.

NBA Jam TE(Genesis) If I could describe this game in 3 words in would be: Infinite Replay Value! From just playing one player to pass a few hours or Playing all night with some friends, I can always put this cart in my Genesis and still have fun. Back in the day me and a friend played the first NBA Jam for his Genesis so much that he ended up having to buy a new cart by the end of the Summer! Now thats a lot of play time!(plus he didn't take that good care of his stuff) lol

Donkey Kong Country 2(SNES) This is my idea of the ultimate platformer, tight gameplay, responsive controls, exciting levels, tons of replay value, plus awesome graphics/music.

Super Mario:RPG(SNES) This was the first RPG I really got into, sure it might be pretty easy and short, but I still have to replay it atleast once a year.