Honestly, I don't think that the cartridge format will ever be obsoleted, at least where handhelds are concerned. They're resistant to damage, they don't skip when the system is jostled, and there's enough storage space for most games. Nobody's ever going to fill a disc with 650 megs of GAMEPLAY, let alone 1.8 gigs... they'll just pad all that extra space with full-motion video and other distractions.
JR