I would say it would be njot so great due to the resolution of the DS. Your character would take up probably a 4th of the screen at actual size...one screen would have to be all HUD (probably the touchscreen since the controls are mouse based anyway). It could be done, but the graphics would have to be scaled way smaller and look like crap, or you wouldn't be able to see around yourself very far.

Thats my off-the-top-of-my-head answer.