I'll second the CDX for best. I don't keep it out, so every time I see it in storage I do a doubletake because of how small it is.

I also really dig the 3do FZ-1. Something about the way it looks like it is on pillars and it is just overall appealing to me. The FZ-10 doesn't do much for me.

For worst I'll have to go along with the SNES sentiments. I think they should have stuck more along the lines of the NES 2, which I rather like.