I wouldn't call load times a non-issue. They're still pretty awful, and so are mandatory installs.

Although it's not exactly the same as the old mask ROM carts, flash memory will be used increasingly, at least on handheld systems.

Personally, I'd love to see a really high end console with a PCIe based cartridge slot that could accommodate cartridges with a wide range of functions. Everything from SSD storage to GPU upgrades would be possible.