As a big fan of Ms. Pac-Man, I must say that no version stands up to an actual arcade cabinet with speed chip. All home ports save for the Genesis one play slow as molasses and make me feel like I'm on cough syrup.

If you really want to play a derivative of Pac-Man at home, go with the Genesis version where you can adjust the speeds. The only problem with this version is that unlike the arcades, the ghosts will travel as fast as you do, making it still different from the arcade classic.