My favorites have always been Harvest Moon 64 and the original SNES game. Although I really liked Save the Homeland on PS2 just because it was so replay able (and as mentioned before, pretty to look at). I got burnt out on the series this generation though. Im not sure which game killed it for me, but I didn't enjoy Rune Factory. After a while all the games just started to blur together.
So... How does the 3DS game compare to the first few games?