Gamestop might have to restructure their business, but so would many of the companies. Sure Nintendo, Activision and EA can probably take to the change, but XSEED, Atlus or NISA isnt going to be able to sell the next Persona, or Phantom Brave at walmart.
I have a Wii U, a Vita and a 3DS to complement my past systems. If the next PS and Xbox wont allow used games I'd gladly pass on them. It will just give me more funds to by used games for consoles I already have.